- December 1, 2017
- Posted by: Neil Wilkie
- Category: Uncategorized
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Disrupted in schizophrenia 1 (DISC1) is a multi-functional scaffolding protein that is associated with neuropsychiatric diseases where, in some instances, DISC1 levels are decreased. This study discovers that DISC1 can be degraded by the ubiquitin proteasome system through a process orchestrated by its interaction with the E3 ubiquitin ligase, FBXW7. Mapping the interaction between DISC1 and FBXW7 allowed disruptors to be generated that inhibited DISC1 degradation, counteracting DISC1 deficiencies found in neural progenitor cells derived from induced pluripotent stem cells of schizophrenia patients.