Phosphodiesterases (PDE)

The PDE superfamily of enzymes comprises 11 forms of PDE (PDE1-11) with additional complexity arising from multiple genes within a particular family, together with the existence of long, short, and super-short isoforms formed by alternative mRNA splicing and the use of alternative promoters. Only PDE 4, 7 and 8 specifically hydrolyse cAMP, whereas other PDEs either hydrolyse another signaling molecule called cGMP (PDEs 5, 6, and 9), or can hydrolyse both cAMP and cGMP (PDEs 1, 2, 3, 10 and 11).

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