LOAC®. PDE4 long form activators

LOAC® – PDE4 long form activators

Mironid’s LoAc® activator program has provided the world’s first discovery of small molecule PDE4 activators. The long-form selective nature of these molecules should provide a novel mechanism of action to treat diseases driven by aberrantly elevated cyclic AMP levels. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an example of such a disease in which genetic mutations drive an elevation in cAMP within the kidney, which leads to the formation of fluid filled cysts within the kidneys, and eventually results in kidney failure.

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