New publication from our CSO

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease

Together with collaborators in the USA and Japan, our CSO has published an article in the prestigious, Journal of Clinical Investigation (JCI), which is a premier venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine.  This research article reports the discovery, structural and functional characterisation of a novel complex formed in the brain between three proteins: PDE4, Huntingtin (HTT) and Disrupted in Schizophrenia (DISC1). The mutant HTT found in Huntington’s Disease, disrupts the normal functioning of this complex, leading to altered PDE4 activity, which is likely to provide the molecular pathology underpinning depression and other psychiatric symptoms seen in HD patients.

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